ה', 02/11/2017 - 12:30 עד 14:00
Orientation and its role in Alzheimer's disease: Mental-orientation is the cognitive function that manages the relationship between the individual and the environment in time (events), space (places) and person (people), as based on a distinct brain system. Observing the clinical similarities between mental-orientation domains and characteristics of Alzheimer’s disease (AD), as well as the striking neuroanatomical overlap between the orientation system and amyloid deposition and brain atrophy in AD, we hypothesized that disturbance of mental-orientation is a core-disorder in AD. In the presentation I will first present the ideas behind mental-orientation as well as its underlying brain system and its relation to the default mode network. I will present the current clinical understanding of Alzheimer’s disease and caveats it poses, and will supply behavioral and neuroimaging data supporting the central role of mental-orientation in the Alzheimer’s disease spectrum. I will conclude with reviewing current efforts in the unified research of space and time and its implication to Alzheimer’s disease.